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Pyrazolopyridine

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Title: Pyrazolopyridine  
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Subject: ICI-190,622, Tracazolate, GABA transaminase inhibitor, (1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid, Gabaculine
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Pyrazolopyridine

Pyrazolo[3,4-b]pyridine, the base chemical structure of this class.

The pyrazolopyridines are a group of drugs investigated as anxiolytics which act as positive allosteric modulators of the GABAA receptor via the barbiturate binding site.[1][2] They include the following compounds:

See also

References

  1. ^ Annual Reports in Medicinal Chemistry: Volume 16. Amsterdam: Elsevier. 1981.  
  2. ^ Progress in Drug Research / Volume 31 (Progress in Drug Research). Boston: Birkhauser. 1987.  


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