Quinazolines

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Quinazoline

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Identifiers
CAS number 253-82-7 YesY
PubChem 9210
ChemSpider 8855 YesY
ChEBI CHEBI:36621 YesY
Jmol-3D images Image 1
Properties
Molecular formula C8H6N2
Molar mass 130.15 g mol−1
Acidity (pKa) 3.51[1]
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Quinazoline is a heterocyclic compound made up of two fused six-membered simple aromatic rings, a benzene ring and a pyrimidine ring. Its chemical formula is C8H6N2. Quinazoline is yellow solid. It is isomeric with other naphthyridines including quinoxaline, phthalazine and cinnoline. Derivatives of quinazoline are called quinazolines.

Medicinally it has been used in various areas especially as an anti-malarial agent and in cancer treatment. One example of a compound containing the quinazoline structure is doxazosin mesylate.

The ring system is typically prepared by heating 2-acylanilides in the presence of ammonia or amines.[1]

See also

References

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