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Rps6ka1

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Rps6ka1

HU-1 redirects here. For the helicopter, see UH-1 Iroquois.

Ribosomal protein S6 kinase, 90kDa, polypeptide 1
2WNT.
Available structures
PDB Ortholog search: RCSB
Identifiers
2.7.11.1
RNA expression pattern

Ribosomal protein S6 kinase alpha-1 is an enzyme that in humans is encoded by the RPS6KA1 gene.[1]

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]

Interactions

RPS6KA1 has been shown to interact with YWHAB,[3] MAPK1,[4][5][6] IκBα,[7] TOB1[8] and TSC2.[9][10]

See also

References

Further reading



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