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Rps6ka3

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Rps6ka3

Ribosomal protein S6 kinase, 90kDa, polypeptide 3
Available structures
PDB Ortholog search: RCSB
Identifiers
2.7.11.1
RNA expression pattern

Ribosomal protein S6 kinase, 90kDa, polypeptide 3, also known as RPS6KA3, is an enzyme that in humans is encoded by the RPS6KA3 gene.[1][2]

Function

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation.[1]

Clinical significance

Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).[3]

Interactions

RPS6KA3 has been shown to interact with CREB-binding protein,[4] MAPK1[5][6] and PEA15.[7]

References

Further reading

External links

  • GeneReviews/NCBI/NIH/UW entry on Coffin-Lowry syndrome



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