World Library  
Flag as Inappropriate
Email this Article
 

Richard F. Heck

Richard F. Heck
Heck in 2010
Born Richard Frederick Heck
(1931-08-15)August 15, 1931
Springfield, Massachusetts, U.S.
Died October 9, 2015(2015-10-09) (aged 84)
Manila, Philippines
Residence Quezon City, Philippines[1][2]
Nationality American
Fields Chemistry
Institutions University of Delaware
Hercules
ETH Zurich
De La Salle University
Alma mater University of California, Los Angeles
Doctoral advisor Saul Winstein
Known for Heck reaction
Notable awards Nobel Prize in Chemistry (2010)
Spouse Socorro Nardo-Heck (died 2012)

Richard Frederick Heck (August 15, 1931 – October 10, 2015) was an reactions that couple aryl halides with alkenes. The analgesic naproxen is an example of a compound that is prepared industrially using the Heck reaction.

For his work in Nobel Prize in Chemistry, shared with the Japanese chemists Ei-ichi Negishi and Akira Suzuki.[3]

Contents

  • Early life and education 1
  • Career 2
    • Palladium-catalyzed coupling reactions 2.1
  • Later life and death 3
  • Honors 4
  • References 5
  • Further reading 6
  • External links 7

Early life and education

Heck was born in Springfield, Massachusetts in 1931.[4] He earned both his bachelor's degree (1952) and his doctor of philosophy degree (1954) at the University of California, Los Angeles (UCLA), working under the supervision of Dr. Saul Winstein. After two periods of postdoctoral research at the ETH in Zurich, Switzerland, and then back at UCLA, Heck took a position with the Hercules Corporation in Wilmington, Delaware in 1957. After productive research work at Hercules, he was hired by the University of Delaware's Department of Chemistry and Biochemistry in 1971. Heck was a professor of chemistry at the University of Delaware. In 2012, he was appointed by De La Salle University in Manila as adjunct professor in its chemistry department.

Career

The development of the arylmercury compounds with olefins using palladium as a catalyst during the late 1960s.[5] This work was published in a series of seven consecutive articles in the Journal of the American Chemical Society (JACS) for which Heck was the sole author.[6][7][8][9][10][11]

During the early 1970s, Mizoroki independently reported the use of the less toxic aryl halides as the coupling partner in the reaction.[12][13] During his career, Heck continued to improve the transformation, developing it into a powerful synthetic method for organic synthesis.

The importance of this reaction grew slowly in the organic synthesis community. In 1982, Heck was able to write an [16]

Palladium-catalyzed coupling reactions

Heck's work set the stage for a variety of other

External links

Further reading

  1. ^
  2. ^
  3. ^
  4. ^
  5. ^
  6. ^
  7. ^
  8. ^
  9. ^
  10. ^
  11. ^
  12. ^
  13. ^ Quality of archived page is low. Full text access requires an account.
  14. ^ Quality of archived page is low. Full text access requires an account.
  15. ^ Quality of archived page is low. Full text access requires an account.
  16. ^
  17. ^ a b First page available free; full text requires purchase. Partial success in archiving.
  18. ^ a b Attempts to archive the target page failed. No free abstract; full text requires payment. (subscription required)
  19. ^ First page available free; full text requires purchase. Partial success in archiving,
  20. ^ .
  21. ^
  22. ^
  23. ^
  24. ^

References

Heck received honorary doctorates from Uppsala University (Pharmacy) and De La Salle University (Science).

Honors

Heck died on October 9, 2015 in Manila in a public hospital.[23][24] His wife predeceased him by 2 years.

Heck moved to the Philippines after retirement [22] in 1989 with his wife, Socorro Nardo-Heck. The couple had no children.

Heck retired from the University of Delaware in 1989, where he became the Willis F. Harrington Professor Emeritus in the Department of Chemistry and Biochemistry. Its annual lectureship was named in his honor in 2004. In 2005, he was awarded the Wallace H. Carothers Award, which recognizes creative applications of chemistry that have had substantial commercial impact. He was awarded the 2006 Herbert C. Brown Award for Creative Research in Synthetic Methods.[20] On 6 October 2010, the Swedish Royal Academy of Sciences awarded Heck the Nobel Prize in Chemistry. He shared the 2010 Glenn T. Seaborg Medal for his work on palladium-catalyzed cross couplings.

Later life and death

Heck's contributions are not limited to the activation of halides by the oxidative addition of palladium. Heck was the first to fully characterize a π-allyl metal complex,[17] and the first to elucidate the mechanism of alkene hydroformylation.[19]

Of the several reactions developed by Heck, the greatest societal impact has been from the palladium-catalyzed coupling of an alkyne with an aryl halide. This is the reaction that was used to couple fluorescent dyes to DNA bases, allowing the automation of DNA sequencing and the examination of the human genome. In Sonogashira's original report of what is now known as the Sonogashira coupling, his group modified an alkyne coupling procedure previously reported by Heck, by adding a copper(I) salt.[18]

[18]

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 


Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.