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Title: Sox6  
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Subject: Transcription factors, NeuroD, EMX homeogene, NOBOX, Winged-helix transcription factors
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SRY (sex determining region Y)-box 6

PDB rendering based on 1i11.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; HSSOX6; SOXD
External IDs GeneCards:
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Transcription factor SOX-6 is a protein that in humans is encoded by the SOX6 gene.[1][2] The SOX gene family encodes a group of transcription factors defined by the conserved high mobility group (HMG) DNA-binding domain. Unlike most transcription factors, SOX transcription factors bind to the minor groove of DNA, causing a 70- to 85-degree bend and introducing local conformational changes.[supplied by OMIM][2]


SOX6 has been shown to interact with CTBP2[3] and CENPK.[4]

It has also been demonstrated that SOX6 protein accumulates in the differentiating human erythrocytes, and then is able to downregulate its own transcription, by directly binding to an evolutionarily conserved consensus sequences located near SOX6 transcriptional start site.[5]

See also


  1. ^ Cohen-Barak O, Hagiwara N, Arlt MF, Horton JP, Brilliant MH (Mar 2001). "Cloning, characterization and chromosome mapping of the human SOX6 gene". Gene 265 (1–2): 157–64.  
  2. ^ a b "Entrez Gene: SOX6 SRY (sex determining region Y)-box 6". 
  3. ^ Murakami A, Ishida S, Thurlow J, Revest JM, Dickson C (August 2001). "SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter". Nucleic Acids Res. 29 (16): 3347–55.  
  4. ^ Yamashita A, Ito M, Takamatsu N, Shiba T (September 2000). "Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis". FEBS Lett. 481 (2): 147–51.  
  5. ^ Cantu' C, Grande V, Alborelli I, Cassinelli L, Cantu' I, Colzani MT, Ierardi R, Ronzoni L, Cappellini MD, Ferrari G, Ottolenghi S, Ronchi A (September 2010). "A highly conserved SOX6 double binding site mediates SOX6 gene downregulation in erythroid cells". Nucleic Acids Res. 39 (2): 486–501.  

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