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Semustine

Semustine
Systematic (IUPAC) name
N-(2-Chloroethyl)-N'-(4-methylcyclohexyl)-N-nitrosourea
Clinical data
Legal status
?
Identifiers
CAS number  YesY
ATC code L01
PubChem
ChemSpider  N
UNII  YesY
KEGG  YesY
ChEBI  N
Chemical data
Formula C10H18ClN3O2 
Mol. mass 247.72 g/mol
 N   

Semustine is a drug used in chemotherapy.[1] It is structurally similar to lomustine, being distinguished from it only by an additional methyl group. It has been taken off the drug market for investigation of its cancerous effects, rated as IARC Group 1 carcinogen or a known carcinogen.

References

  1. ^ "Radiation therapy and fluorouracil with or without semustine for the treatment of patients with surgical adjuvant adenocarcinoma of the rectum. Gastrointestinal Tumor Study Group". Journal of clinical oncology : official journal of the American Society of Clinical Oncology 10 (4): 549–557. 1992.  


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