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Sodium orthovanadate

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Title: Sodium orthovanadate  
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Subject: Sodium vanadate, Vanadate, Inorganic compounds, Sodium cyanoborohydride, Sodium nitride
Collection: Inorganic Compounds, Sodium Compounds, Vanadates
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Sodium orthovanadate

Sodium orthovanadate
Names
IUPAC name
Sodium vanadate(V)
Other names
sodium vanadate (V),
sodium vanadium oxide
Identifiers
 Y
ChEMBL  N
Jmol-3D images Image
PubChem
RTECS number YW1120000
Properties
Na3VO4
Molar mass 183.908 g/mol
Appearance white powder
Density 2.16 g/cm³, solid
Melting point 858 °C (1,576 °F; 1,131 K)
22.17 g/100 mL
Solubility insoluble in ethanol
Structure
cubic
Thermochemistry
164.8 J/mol K
190 J/mol K
-1757 kJ/mol
Hazards
Main hazards Harmful.
NFPA 704
1
2
0
Flash point Non-flammable
Lethal dose or concentration (LD, LC):
LD50 (Median dose)
330 mg/kg (oral, rat)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N  (: Y/N?)

Sodium orthovanadate is the chemical compound Na3VO4 and contains the tetrahedral VO43−.[1] It is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue. The VO43− ion binds reversibly to the active sites of most protein tyrosine phosphatases.

It is often added to buffer solutions that are used in protein analysis in molecular biology. The aim is to preserve the phosphorylation of proteins of interest by inhibiting endogenous phosphatases present in cell lysate mixture. It is commonly used at a final working concentration of 1 - 10 mM. It is toxic when inhaled, swallowed or in contact with skin.

Synthesis

Sodium orthovanadate is created by dissolving vanadium(V) oxide in a solution of sodium hydroxide.

References

  1. ^  
Swarup, G. et al. Biochem. Biophys. Res. Comm. 107: 1104-1109 (1982).

See also

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