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Tnfrsf10a

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Tnfrsf10a

Tumor necrosis factor receptor superfamily, member 10a
Identifiers
TNFRSF10A Gene
Orthologs
SpeciesHumanMouse

Tumor necrosis factor receptor superfamily member 10A is a protein that in humans is encoded by the TNFRSF10A gene.[1][2] also known as DR4 or TRAIL-R1

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.[3]

Interactions

TNFRSF10A has been shown to interact with DAP3.[4]

References

Further reading

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