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Tnfrsf10b

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Subject: Killer, TRAIL, Tumor necrosis factor receptor, FADD, List of therapeutic monoclonal antibodies, Caspase 8, Tigatuzumab
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Tnfrsf10b

Tumor necrosis factor receptor superfamily, member 10b
PDB rendering based on 1d0g.
Available structures
PDB Ortholog search: RCSB
Identifiers
TNFRSF10B Gene
RNA expression pattern

Tumor necrosis factor receptor superfamily, member 10b, official symbol TNFRSF10B, is a human gene. Also known as: DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. Mice have a homologous gene, tnfrsf10b, that has been essential in the elucidation of the function of this gene in humans. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.[1]

Interactions

TNFRSF10B has been shown to interact with FADD,[2][3] TRAIL,[4][5][6] Caspase 10[2][7] and Caspase 8.[2][7]

See also

References

Further reading

External links

  • Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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