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Tnfrsf13b

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Subject: Selective immunoglobulin A deficiency, Tumor necrosis factor receptor, B-cell activating factor, TRAF6, TRAF2
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Tnfrsf13b

Tumor necrosis factor receptor superfamily, member 13B
PDB rendering based on 1xu1.
Available structures
PDB Ortholog search: RCSB
Identifiers
TNFRSF13B Gene
RNA expression pattern

Tumor necrosis factor receptor superfamily member 13B, also known as TNFRSF13B or more commonly as TACI, is a transmembrane receptor protein found predominantly on the surface of B cells, which are an important part of the immune system.[1]

TACI is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It was originally discovered because of its ability to interact with calcium-modulator and cyclophilin ligand (CAML). TACI was later found to play a crucial role in humoral immunity by interacting with two members of the TNF family: BAFF and APRIL. These proteins signal through TACI inducing activation of several transcription factors including NFAT, AP-1, and NF-kappa-B which then modulate cellular activities. Defects in the function of TACI can lead to immune system diseases.

Functions of TACI

TACI controls T cell-independent B cell antibody responses, isotype switching, and B cell homeostasis.

Medical significance

TACI mutations are associated with immunodeficiency in humans, as a significant proportion of CVID patients have TACI mutations. People with this condition produce abnormally low amounts of antibodies, which are needed for protection against infections.

In humans, the gene encoding this protein is located within the Smith-Magenis syndrome region on chromosome 17.[1]

Interactions

TNFRSF13B has been shown to interact with B-cell activating factor,[2][3] TRAF6,[3] TRAF5,[3] TNFSF13,[2] TRAF2[3] and CAMLG.[3][4]

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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