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Tnfrsf17

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Subject: B cell, Tumor necrosis factor receptor, Belimumab, B-cell activating factor, BCMA
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Tnfrsf17

Tumor necrosis factor receptor superfamily, member 17
PDB rendering based on 1oqd.
Available structures
PDB Ortholog search: RCSB
Identifiers
TNFRSF17 Gene
RNA expression pattern
BCMA TALL-1 binding domain
crystal structure of stall-1 and bcma
Identifiers
Symbol BCMA-Tall_bind
Pfam InterPro IPR015337
SCOP SUPERFAMILY 1oqd

Tumor necrosis factor receptor superfamily member 17 is a protein that in humans is encoded by the TNFRSF17 gene.[1][2][3]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.[3]

Interactions

TNFRSF17 has been shown to interact with the B-cell activating factor TNFSF13B.[4][5] A conserved domain at the N-terminus, BCMA TALL-1 binding domain, is required for binding to the TNFSF13B.[4]

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article incorporates text from the IPR015337


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