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Tetracosactide

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Tetracosactide

Tetracosactide
Systematic (IUPAC) name
L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-proline
Clinical data
AHFS/Drugs.com
Identifiers
CAS Registry Number  YesY
ATC code H01
PubChem CID:
IUPHAR/BPS
DrugBank  YesY
ChemSpider  YesY
UNII  YesY
KEGG  YesY
ChEBI  YesY
Synonyms Ba 30920
α1–24 corticotrophin
Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro
Chemical data
Formula C136H210N40O31S
Molecular mass 2933.44 g/mol
 N   

Tetracosactide (synthetic peptide and analogue of adrenocorticotrophic hormone (ACTH) which is used clinically as a diagnostic agent.[1][2][3] It consists of the first 24 (of a total of 39) amino acids of ACTH and retains full function of the parent peptide.[1][4] Tetracosactide stimulates the release of corticosteroids such as cortisol from the adrenal glands, and is used for the ACTH stimulation test to assess adrenal gland function.[2]

Contents

  • Uses 1
  • Pharmacology 2
  • See also 3
  • References 4
  • External links 5

Uses

Tetracosactide is used for diagnostic purposes (e.g. in short synacthen test). It is suitable for treatment of adrenal insufficiency of central origin. Synacthen is also being used in treatment of different types of drug registant epilepsia, particularly by pediatric neurologists.

In patients with low cortisol levels or symptoms of adrenocortical insufficiency, tetracosactide can be used to diagnose Addison's disease. A failure for serum cortisol levels to increase after administration of tetracosactide makes a diagnosis of primary adrenocortical insufficiency more likely. An increase in cortisol upon administration of tetracosactide rules out the condition. The test may also be used to assess the function of the adrenal glands after successful treatment for Cushing's syndrome.

Tetracosactide is also used in the opposite situation, when there is aldosterone hypersecretion due to either a unilateral adrenal adenoma (which is treated by surgical removal) or bilateral adrenal hyperplasia (treated by oral spironolactone). A procedure called adrenal venous sampling may be used pre-operatively to localize the source of aldosterone hypersecretion from either adrenal gland. A peripheral intravenous infusion of tetracosactide before and during the procedure stimulates cortisol production and thereby verifies catheter position.[5]

As well as its legitimate medical applications, it has been widely reported that tetracosactide has also been used as an illegal performance-enhancing drug by professional cyclists.[6] It is known to be used as a doping agent to increase the secretion of glucocorticoids by adrenal glands.[7]

Tetracosactide has been used in the treatment of infantile spasms.[8]

Types of drug resistant epilepsy that can be treated with Synacthen:

Pharmacology

In the normal situation, ACTH is released from the pituitary gland at the base of the brain. It acts on the adrenal glands to stimulate the production of steroid hormones (glucocorticoids). If the adrenal glands are healthy, a single injection of tetracosactide results in a rise in blood cortisol (hydrocortisone) concentrations in 30 minutes. If the adrenal glands appear not to be working then tetracosactide injection can be given to check whether the problem is due to diseased or damaged adrenals or due to lack of pituitary ACTH.

See also

References

  1. ^ a b
  2. ^ a b
  3. ^
  4. ^ Cortrosyn information
  5. ^
  6. ^
  7. ^
  8. ^

External links

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