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Tumor necrosis factor-beta

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Tumor necrosis factor-beta

Lymphotoxin alpha (TNF superfamily, member 1)
PDB rendering based on 1tnr.
Available structures
PDB Ortholog search: RCSB
Identifiers
LTA Gene
RNA expression pattern

Lymphotoxin-alpha (LT-alpha) is a protein that in humans is encoded by the LTA gene.[1][2]

Function

Lymphotoxin alpha, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. LTA is highly inducible, secreted, and exists as homotrimeric molecule. LTA forms heterotrimers with lymphotoxin-beta, which anchors lymphotoxin-alpha to the cell surface. LTA mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. LTA is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis.[3]

In LTα knockout mice, all Peyer's patches and lymph nodes will fail to develop indicating LTα's importance in immunological development.[4]

Interactions

Lymphotoxin alpha has been shown to interact with LTB.[5][6][7]

See also

References

Further reading


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