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Vindesine

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Title: Vindesine  
Author: World Heritage Encyclopedia
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Subject: List of chemotherapeutic agents, Mitotic inhibitor, List of MeSH codes (D03), Chemotherapy, Cell-cycle nonspecific antineoplastic agents
Collection: Mitotic Inhibitors, Vinca Alkaloids
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Vindesine

Vindesine
Systematic (IUPAC) name
methyl (5S,7S,9S)- 9-[(2β,3β,4β,5α,12β,19α)- 3-(aminocarbonyl)- 3,4-dihydroxy- 16-methoxy- 1-methyl- 6,7-didehydroaspidospermidin- 15-yl]- 5-ethyl- 5-hydroxy- 1,4,5,6,7,8,9,10-octahydro- 2H- 3,7-methanoazacycloundecino[5,4-b]indole- 9-carboxylate
Clinical data
AHFS/Drugs.com
Pregnancy
category
  • AU: D
Legal status
  • (Prescription only)
Routes of
administration
Intravenous
Pharmacokinetic data
Protein binding 65-75%
Metabolism Hepatic (CYP3A4-mediated)
Biological half-life 24 hours
Excretion Biliary and renal
Identifiers
CAS Registry Number  Y
ATC code L01
PubChem CID:
DrugBank  Y
ChemSpider  Y
UNII  Y
KEGG  Y
ChEBI  Y
ChEMBL  Y
Chemical data
Formula C43H55N5O7
Molecular mass 753.926 g/mol
 Y   

Vindesine is an anti-mitotic vinca alkaloid used in chemotherapy. It is used to treat many different types of cancer, including leukaemia, lymphoma, melanoma, breast cancer, and lung cancer.[1]

References

  1. ^ Vindesine (Eldisine) : Cancerbackup
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