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Title: Znf300  
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Subject: NeuroD, EMX homeogene, Engrailed (gene), Nur (biology), Early growth response proteins
Collection: Transcription Factors
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Zinc finger protein 300
Symbols  ; DKFZp686B24204
External IDs GeneCards:
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Zinc finger protein 300 is a protein that in humans is encoded by the ZNF300 gene.[1][2] The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and a likely transcription factor.

Clinical relevance

It is associated with Crohn's disease.[3]


  1. ^ Gou D, Wang J, Gao L, Sun Y, Peng X, Huang J, Li W (January 2004). "Identification and functional analysis of a novel human KRAB/C2H2 zinc finger gene ZNF300". Biochim. Biophys. Acta 1676 (2): 203–9.  
  2. ^ "Entrez Gene: zinc finger protein 300". 
  3. ^ Prescott NJ, Dominy KM, Kubo M, Lewis CM, Fisher SA, Redon R, Huang N, Stranger BE, Blaszczyk K, Hudspith B, Parkes G, Hosono N, Yamazaki K, Onnie CM, Forbes A, Dermitzakis ET, Nakamura Y, Mansfield JC, Sanderson J, Hurles ME, Roberts RG, Mathew CG (May 2010). "Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease". Hum. Mol. Genet. 19 (9): 1828–39.  

Further reading

  • Feng T, Zhu X (2010). "Genome-wide searching of rare genetic variants in WTCCC data.". Hum. Genet. 128 (3): 269–80.  
  • Qiu H, Xue L, Gao L, et al. (2008). "Identification of the DNA binding element of the human ZNF300 protein.". Cell. Mol. Biol. Lett. 13 (3): 391–403.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7.  
  • Xu JH, Wang T, Wang XG, et al. (2010). "PU.1 can regulate the ZNF300 promoter in APL-derived promyelocytes HL-60.". Leuk. Res. 34 (12): 1636–46.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5.  
  • Xue L, Qiu H, Ma J, et al. (2010). "ZNF300, a recently identified human transcription factor, activates the human IL-2Rβ promoter through the overlapping ZNF300/EGR1 binding site.". Cell. Mol. Biol. Lett. 15 (4): 530–40.  
  • Oh JH, Yang JO, Hahn Y, et al. (2005). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.  
  • Cao Y, Li JX, Ji CN, et al. (2007). "Molecular cloning and characterization of a novel splice variant of human ZNF300 gene, which expressed highly in testis.". DNA Seq. 18 (4): 312–5.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65.  
  • "Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.". Nature 447 (7145): 661–78. 2007.  

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