Zearalanol

Zeranol
Identifiers
CAS number 26538-44-3 N
PubChem 33534
ChemSpider 4447689 YesY
Jmol-3D images Image 1
Properties
Molecular formula C18H26O5
Molar mass 322.40 g mol−1
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Zeranol (α-zearalanol) is a non-steroidal estrogen agonist. It is a mycotoxin, derived from fungi in the Fusarium family, and may be found as a contaminant in fungus-infected crops. It is 3-4x more potent as an estrogen agonist than the related compound zearalenone.[1]

Zeranol is approved for use as a growth promoter in livestock, including beef cattle, in the United States. In Canada, it is approved for use in beef cattle only.[2] Its application is not approved for use in the European Union.

Zeranol increases cancer cell proliferation in already existing breast cancer.[3] There are mixed results to whether zeranol has anticancer or carcinogenic properties in non cancer containing breast cells depending on dose.[3] Overall evidence points to zeranol being a risk factor and promoter for cancer.[3] However, dietary exposure from the use of zeranol-containing implants in cattle is insignificant.[4]


References


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