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How Translational Medicine Is Progressively Redefining Healthcare : From bench to bedside, the patient is the bedrock of translational research

By Dufour, Fritz

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Book Id: WPLBN0100002604
Format Type: PDF (eBook)
File Size: 744.79 KB.
Reproduction Date: 12/19/2017

Title: How Translational Medicine Is Progressively Redefining Healthcare : From bench to bedside, the patient is the bedrock of translational research  
Author: Dufour, Fritz
Volume:
Language: English
Subject: Non Fiction, Medicine, Translation medicine
Collections: Authors Community, Science
Historic
Publication Date:
2017
Publisher: Self-published
Member Page: Fritz Dufour

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Dufour, F. (2017). How Translational Medicine Is Progressively Redefining Healthcare : From bench to bedside, the patient is the bedrock of translational research. Retrieved from http://www.self.gutenberg.org/


Description
The preliminary idea behind translational medicine, conducting biological research to treat diseases, is not a new concept. But, scientists have been serious about placing the patient at all levels of the research process – right at the basic science level phase and all the way to the bedside – since only the 1990s. Today, translational research is a scientific field, although multidisciplinary. That innovation stemmed from the discoveries of new diseases and new technologies that allow healthcare professionals to have new perspectives on how to better and more efficiently treat patients. Translational medicine is viable, and it has already proved itself in many areas. Normally, every great discovery or innovation comes with both rewards and challenges, and continuous improvement is what keeps it alive. Translational research, an innovative concept, is not impervious to that rule. This paper examines the antecedents of translational medicine and how it came about. It considers the importance of incorporating basic science, applied science or clinical research, and the patient at every turn of the processes by analyzing the importance of translational research and its direct applications. On the other hand, this paper considers the challenges faced by translational medicine in an age where healthcare costs are skyrocketing, and suggests what can be done to circumvent the downsides. Finally, because the field is relatively new and promising, the discussion that follows also considers the outlook for translational medicine, and how important it is for scientists – artificial intelligence experts, computer, or bioengineers, healthcare professionals and healthcare management professionals – to lay right now the groundwork for future generations.

Summary
The preliminary idea behind translational medicine, conducting biological research to treat diseases, is not a new concept. But, scientists have been serious about placing the patient at all levels of the research process – right at the basic science level phase and all the way to the bedside – since only the 1990s. Today, translational research is a scientific field, although multidisciplinary. That innovation stemmed from the discoveries of new diseases and new technologies that allow healthcare professionals to have new perspectives on how to better and more efficiently treat patients. Translational medicine is viable, and it has already proved itself in many areas. Normally, every great discovery or innovation comes with both rewards and challenges, and continuous improvement is what keeps it alive. Translational research, an innovative concept, is not impervious to that rule. This paper examines the antecedents of translational medicine and how it came about. It considers the importance of incorporating basic science, applied science or clinical research, and the patient at every turn of the processes by analyzing the importance of translational research and its direct applications. On the other hand, this paper considers the challenges faced by translational medicine in an age where healthcare costs are skyrocketing, and suggests what can be done to circumvent the downsides. Finally, because the field is relatively new and promising, the discussion that follows also considers the outlook for translational medicine, and how important it is for scientists – artificial intelligence experts, computer, or bioengineers, healthcare professionals and healthcare management professionals – to lay right now the groundwork for future generations.

Excerpt
Translational medicine or translation research is an umbrella term that covers specific research in biological sciences whose main goal is to increase human life expectancy by keeping us healthy (from better ideas to better health). It’s synonymous with translational medical science, disease-targeted research, or evidence-based research. Translation research is particular because of its bidirectional nature. It’s commonly called the B2B approach or bench to bedside approach because it incorporates clinical skills and observations as well as scientific hypotheses utilized by researchers in the laboratories. The whole concept functions in a loop: bench to bedside and back. It translates knowledge, skills, or science from one place to another not only by focusing on the traditional 4P-Medicine – personalization, prevention, prediction, and participation – but also by taking into consideration another 3 Ps: providing (staff training), preemptive (research and development), and point of care (making sure that healthcare can be given anytime anywhere). Because of that, translational medicine can be viewed as a paradigm shift. This revolutionary concept shows how research discoveries can translate into effective therapies… Moreover, the understanding of disease pathology and preclinical models (their availability, their relevance to the disease and their translatability are considered key focus of modern translation research or translational medicine. Disease pathology may differ from one individual to the next. Researchers in the biological and the medical fields understand that. Thus, today, pharmacogenomics or personalized medicine is a field in the making and is set to revolutionized how patients are treated because the one size fits all approach is becoming more and more a thing of the past. Disease pathology also prompts researchers to consider our genetic makeups or our DNA first thing when trying to invent drugs or medical techniques likely to improve or enhance life expectancy.

Table of Contents
Summary..…………………………………………………………………………………………3 1. From astrological and herbal medicines to translational medicine…………………………....3 Bridge to modern translational research………………………………………………………….4 a. Before the 21st century…………………………………………………………………....4 b. In the 21st century………………………………………………………………………....5 2. What is translational medicine?.................................................................................................6 a. Historical perspective and origin of translational medicine………………………………7 b. Modern view and definition of translational medicine……………………………………7 c. Characteristics and processes of translational research…………………………………...8 3. Importance of translational medicine…………………………………………………………10 a. Why does translational medicine matter?..........................................................................10 b. Direct applications of translational research……………………………………………..11 • The pharmaceutical industry…………………………………………………………11 • Neuroscience…………………………………………………………………………13 • Cancer treatment……………………………………………………………………..14 • Medical robotics……………………………………………………………………...15 4. Barriers to translational medicine…………………………………………………………….16 5. Overcoming the barriers……………………………………………………………………...19 6. Outlook for translational medicine…………………………………………………………...21 7. Sources………………………………………………………………………………………..23 8. From the same author…………………………………………………………………………23


 

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