In her introduction to the 1974 edition, Joan Quixley, then head of the Nightingale School of Nursing, wrote that despite the passage of time since Notes on Nursing was published, "the book astonishes one with its relevance to modern attitudes and skills in nursing, whether this be practised at home by the 'ordinary woman', in hospital or in the community. The social, economic and professional differences of the nineteenth and twentieth centuries in no way hinder the young student or pupil from developing, if he or she is motivated to do so, its unchanged fundamentals by way of intelligent thought and practice". "With its mid-nineteenth century background of poverty, neglect, ignorance and prejudice the book was a challenge to contemporary views of nursing, of nurses and of the patient". "The book was the first of its kind ever to be written. It appeared at a time when the simple rules of health were only beginning to be known, when its topics were of vital importance not only for the well-being and recovery of patients, when hospitals were riddled with infection, when nurses were still mainly regarded as ignorant, uneducated person...

The book included advice and practices for the following areas: ventilation and warming health in houses petty management (how things are done by others when you must be away) noise variety (environment) taking food and what kinds of food bed and bedding light cleanliness of rooms personal cleanliness chattering hopes and advices (the false assurances and recommendations of family and friends to the sick) observation of the sick ...