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Sodium channel, non-voltage-gated 1, gamma subunit
Symbols  ; BESC3; ENaCg; ENaCgamma; PHA1; SCNEG
External IDs IUPHAR: ChEMBL: GeneCards:
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Amiloride-sensitive sodium channel subunit gamma is a protein that in humans is encoded by the SCNN1G gene.[1][2]

See also


SCNN1G has been shown to interact with STX1A,[3] Ubiquitin C[4][5] and NEDD4.[6][7][8]


  1. ^ Voilley N, Bassilana F, Mignon C, Merscher S, Mattei MG, Carle GF, Lazdunski M, Barbry P (January 1996). "Cloning, chromosomal localization, and physical linkage of the beta and gamma subunits (SCNN1B and SCNN1G) of the human epithelial amiloride-sensitive sodium channel". Genomics 28 (3): 560–5.  
  2. ^ "Entrez Gene: SCNN1G sodium channel, nonvoltage-gated 1, gamma". 
  3. ^ Berdiev, Bakhrom K; Jovov Biljana; Tucker Ward C; Naren Anjaparavanda P; Fuller Catherine M; Chapman Edwin R; Benos Dale J (June 2004). "ENaC subunit-subunit interactions and inhibition by syntaxin 1A". Am. J. Physiol. Renal Physiol. (United States) 286 (6): F1100–6.  
  4. ^ Boulkroun, Sheerazed; Ruffieux-Daidié Dorothée, Vitagliano Jean-Jacques, Poirot Olivier, Charles Roch-Philippe, Lagnaz Dagmara, Firsov Dmitri, Kellenberger Stephan, Staub Olivier (October 2008). "Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3". Am. J. Physiol. Renal Physiol. (United States) 295 (4): F889–900.  
  5. ^ Raikwar, Nandita S; Thomas Christie P (May 2008). "Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel". Am. J. Physiol. Renal Physiol. (United States) 294 (5): F1157–65.  
  6. ^ Farr, T J; Coddington-Lawson S J; Snyder P M; McDonald F J (February 2000). -channel subunits"+ channel: WW3 but not WW1 binds to Na+"Human Nedd4 interacts with the human epithelial Na. Biochem. J. (England) 345 (3): 503–9.  
  7. ^ McDonald, Fiona J; Western Andrea H; McNeil John D; Thomas Brittany C; Olson Diane R; Snyder Peter M (September 2002). "Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel". Am. J. Physiol. Renal Physiol. (United States) 283 (3): F431–6.  
  8. ^ Harvey, K F; Dinudom A; Cook D I; Kumar S (March 2001). "The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel". J. Biol. Chem. (United States) 276 (11): 8597–601.  

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