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Mantle zone

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Title: Mantle zone  
Author: World Heritage Encyclopedia
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Subject: Outline of immunology, Lymphocytic leukemia, Diffuse infiltrative lymphocytosis syndrome, Primary mediastinal B-cell lymphoma, Large-cell lymphoma
Collection: Lymphatic Organ Anatomy
Publisher: World Heritage Encyclopedia

Mantle zone

Germinal centre
Image labeled in German, but "Mantel-zone" visible near center.
Anatomical terminology

The mantle zone (or just mantle) of a lymphatic nodule (or lymphatic follicle) is an outer ring of small lymphocytes surrounding a germinal center.[1]

It is also known as the "corona".[2]

It contains transient lymphocytes.[3]

It is the location of the lymphoma in mantle cell lymphoma.


Intermediate magnification micrograph of Castleman disease showing the characteristic expansion of the mantle zone. H&E stain.

Mantle zone expansion may be seen in benign, such as Castleman disease, and malignancy, i.e. Mantle cell lymphoma.


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External links

  • Histology image: 07102loa - Histology Learning System at Boston University - "Lymphoid Tissues and Organs: lymph node, cortex and medulla"
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