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Delmadinone acetate

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Title: Delmadinone acetate  
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Subject: Progestogens, Veterinary medicine, Chlormadinone acetate, Algestone acetophenide, Dimethisterone
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Delmadinone acetate

Delmadinone acetate
Systematic (IUPAC) name
6-chloro-3,20-dioxopregna-1,4,6-trien-17-yl acetate
Clinical data
Legal status
?
Identifiers
CAS number
ATCvet code QG03
PubChem
ChemSpider
ChEMBL
Chemical data
Formula C23H27ClO4 
Mol. mass 402.911 g/mol

Delmadinone acetate (INN, USAN, BAN; sold under brand names including Delmate, Estrex, Tardak, Tardastren, Tardastrex, Vetadinon, and Zenadrex), sometimes abbreviated as DMA, is a steroidal progestin with antigonadotropic (and hence, antiandrogenic and antiestrogenic) properties which is used to treat androgen-associated conditions in veterinary medicine.[1][2][3] It must be used with care as it has the potential to cause adrenal insufficiency via inhibition of adrenocorticotropic hormone (ACTH) secretion from the pituitary gland.[4]

Synthesis

Delmadinone acetate is made by the SeO2 oxidation of Chlormadinone acetate.

Delmadinone acetate synthesis:[5]

See also

References

  1. ^ F.. Macdonald (1997). Dictionary of Pharmacological Agents. CRC Press. p. 579.  
  2. ^ Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 298.  
  3. ^ Dr. Ian Morton; Ian K. M. Morton; Judith M. Hall; Dr. Judith Hall (1999). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer. p. 92.  
  4. ^ Court EA, Watson AD, Church DB, Emslie DR (August 1998). "Effects of delmadinone acetate on pituitary-adrenal function, glucose tolerance and growth hormone in male dogs". Australian Veterinary Journal 76 (8): 555–60.  
  5. ^ Ringold, H. J.; Batres, E.; Bowers, A.; Edwards, J.; Zderic, J. (1959). "Steroids. Cxxvii.16-Halo Progestational Agents". Journal of the American Chemical Society 81 (13): 3485.  


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