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Acid phosphatase

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Title: Acid phosphatase  
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Subject: Prostatic acid phosphatase, R.EcoRII, EC 3.1.3.2, Biochemistry, Pre-ejaculate
Collection: Biochemistry, Ec 3.1.3.2
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Acid phosphatase

Acid phosphatase
Identifiers
EC number 3.1.3.2
CAS number 9001-77-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Acid phosphatase (EC 3.1.3.2, acid phosphomonoesterase, phosphomonoesterase, glycerophosphatase, acid monophosphatase, acid phosphohydrolase, acid phosphomonoester hydrolase, uteroferrin, acid nucleoside diphosphate phosphatase, orthophosphoric-monoester phosphohydrolase (acid optimum)) is a phosphatase, a type of enzyme, used to free attached phosphoryl groups from other molecules during digestion. It can be further classified as a phosphomonoesterase. Acid phosphatase is stored in lysosomes and functions when these fuse with endosomes, which are acidified while they function; therefore, it has an acid pH optimum.[1] This enzyme is present in many animal and plant species.[2]

Different forms of acid phosphatase are found in different serum levels are used to evaluate the success of the surgical treatment of prostate cancer.[1] In the past, they were also used to diagnose this type of cancer.

Reference ranges for blood tests, showing acid phosphatase in red at left.

Acid phosphatase catalyzes the following reaction at an optimal acidic pH (below 7):

Orthophosphoric monoester + H2O → alcohol + H3PO4

Phosphatase enzymes are also used by soil microorganisms to access organically bound phosphate nutrients. An assay on the rates of activity of these enzymes may be used to ascertain biological demand for phosphates in the soil.

Some plant roots, especially cluster roots, exude carboxylates that perform acid phosphatase activity, helping to mobilise phosphorus in nutrient-deficient soils.

Certain bacteria like Nocardia, can degrade this enzyme and utilize it as a carbon source

Contents

  • Bone acid phosphatase 1
  • Genes 2
  • References 3
  • See also 4
    • Internal links 4.1
  • External links 5

Bone acid phosphatase

Tartrate-resistant acid phosphatase may be used as a biochemical marker of osteoclast function during the process of bone resorption.[3]

Genes

The following genes encode the polypeptide components for various acid phosphatase isoenzymes.

References

  1. ^ a b Henneberry, M.O.; Engel, G.; Grayhack, J.T. (October 1979). "Acid phosphatase". The Urologic clinics of North America 6 (3): 629–41. Retrieved 11 May 2015. 
  2. ^ Bull, H.; Murray, P.G.; Thomas, D.; Fraser, A.M.; Nelson, P.N. (April 2002). "Acid phosphatases". Molecular Pathology 55 (2): 65–72. Retrieved 11 May 2015. 
  3. ^ Minkin, Cedrick (1982). "Bone Acid Phosphatase: Tartrate-resistant Acid Phosphatase as a Marker of Osteoclast Function". Calcified Tissue International 34: 285–290. Retrieved 11 May 2015. 

See also

Internal links

External links

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