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Aclarubicin

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Title: Aclarubicin  
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Aclarubicin

Aclarubicin
Systematic (IUPAC) name
(1S,2S,4R)-Methyl 4-(((2S,5R,6R)-4-(dimethylamino)-5-(((1S,3R,4S)-3-hydroxy-5-methyl-4-(((2S,6R)-6-methyl-5-oxotetrahydro-2H-pyran-2-yl)oxy)cyclohexyl)oxy)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate
Clinical data
AHFS/Drugs.com
Legal status
  • Prescription only
Routes IV
Identifiers
CAS number  N
ATC code L01
PubChem
ChemSpider  YesY
UNII  YesY
KEGG  YesY
ChEBI  N
ChEMBL  N
Chemical data
Formula C42H53NO15 
Mol. mass 811.86 g/mol
 N   

Aclarubicin (INN) or aclacinomycin A[1] is an anthracycline drug[2] that is used in the treatment of cancer. Soil bacteria Streptomyces galilaeus can produce aclarubicin.

References

  1. ^ PubChem 451415
  2. ^ Jensen PB, Jensen PS, Demant EJ, et al. (October 1991). "Antagonistic effect of aclarubicin on daunorubicin-induced cytotoxicity in human small cell lung cancer cells: relationship to DNA integrity and topoisomerase II". Cancer Res. 51 (19): 5093–9.  


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