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Title: Ccl4  
Author: World Heritage Encyclopedia
Language: English
Subject: Chemokine, CCR5, Chromosome 17 (human), Macrophage inflammatory protein, CCL3, CCL14, CC chemokine receptors
Publisher: World Heritage Encyclopedia


For carbon tetrachloride, with formula CCl4, see Carbon tetrachloride.
Chemokine (C-C motif) ligand 4
PDB rendering based on 1hum.
Available structures
PDB Ortholog search: RCSB
CCL4 Gene
RNA expression pattern

Chemokine (C-C motif) ligand 4, also known as CCL4, is a protein which in humans is encoded by the CCL4 gene.[1]


CCL4, also known as Macrophage inflammatory protein-1β (MIP-1β) is a CC chemokine with specificity for CCR5 receptors. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells.[2]

CCL4 is a major HIV-suppressive factor produced by CD8+ T cells.[3]

Perforin-low memory CD8+ T cells that normally synthesize MIP-1-beta.[4]


CCL4 has been shown to interact with CCL3.[5]

See also


Further reading

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