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Cd164

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Title: Cd164  
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Cd164

CD164 molecule, sialomucin
Identifiers
Symbols  ; MGC-24; MUC-24; endolyn
External IDs GeneCards:
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Sialomucin core protein 24 also known as endolyn or CD164 (cluster of differentiation 164) is a protein that in humans is encoded by the CD164 gene.[1][2] CD164 functions as a cell adhesion molecule.

Sialomucins are a heterogeneous group of secreted or membrane-associated mucins that appear to play two key but opposing roles in vivo: first as cytoprotective or antiadhesive agents, and second as adhesion receptors. CD164 is a type I integral transmembrane sialomucin that functions as an adhesion receptor.[1]

References

  1. ^ a b Watt SM, Bühring HJ, Rappold I, Chan JY, Lee-Prudhoe J, Jones T, Zannettino AC, Simmons PJ, Doyonnas R, Sheer D, Butler LH (August 1998). "CD164, a novel sialomucin on CD34(+) and erythroid subsets, is located on human chromosome 6q21". Blood 92 (3): 849–66.  
  2. ^ Zannettino AC, Bühring HJ, Niutta S, Watt SM, Benton MA, Simmons PJ (October 1998). "The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis". Blood 92 (8): 2613–28.  

Further reading

  • Zannettino AC (2001). "CD164.". J. Biol. Regul. Homeost. Agents 15 (4): 394–6.  
  • Masuzawa Y, Miyauchi T, Hamanoue M; et al. (1992). "A novel core protein as well as polymorphic epithelial mucin carry peanut agglutinin binding sites in human gastric carcinoma cells: sequence analysis and examination of gene expression.". J. Biochem. 112 (5): 609–15.  
  • Zhou GQ, Zhang Y, Ferguson DJ; et al. (2006). "The Drosophila ortholog of the endolysosomal membrane protein, endolyn, regulates cell proliferation.". J. Cell. Biochem. 99 (5): 1380–96.  
  • Chan JY, Lee-Prudhoe JE, Jorgensen B; et al. (2001). "Relationship between novel isoforms, functionally important domains, and subcellular distribution of CD164/endolyn.". J. Biol. Chem. 276 (3): 2139–52.  
  • Ganesh SK, Zakai NA, van Rooij FJ; et al. (2009). "Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium". Nat. Genet. 41 (11): 1191–8.  
  • Barbe L, Lundberg E, Oksvold P; et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell Proteomics 7 (3): 499–508.  
  • Kurosawa N, Kanemitsu Y, Matsui T; et al. (1999). "Genomic analysis of a murine cell-surface sialomucin, MGC-24/CD164". Eur. J. Biochem. 265 (1): 466–72.  
  • Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11.  
  • Doyonnas R, Yi-Hsin Chan J, Butler LH; et al. (2000). "CD164 monoclonal antibodies that block hemopoietic progenitor cell adhesion and proliferation interact with the first mucin domain of the CD164 receptor". J. Immunol. 165 (2): 840–51.  
  • Gudbjartsson DF, Walters GB, Thorleifsson G; et al. (2008). "Many sequence variants affecting diversity of adult human height". Nat. Genet. 40 (5): 609–15.  
  • Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806.  
  • Oh JH, Yang JO, Hahn Y; et al. (2005). "Transcriptome analysis of human gastric cancer". Mamm. Genome 16 (12): 942–54.  
  • Havens AM, Jung Y, Sun YX; et al. (2006). "The role of sialomucin CD164 (MGC-24v or endolyn) in prostate cancer metastasis". BMC Cancer 6: 195.  
  • Forde S, Tye BJ, Newey SE; et al. (2007). "Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells". Blood 109 (5): 1825–33.  
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.  
  • Hennersdorf F, Florian S, Jakob A; et al. (2005). "Identification of CD13, CD107a, and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-dependent upregulation". Cell Res. 15 (5): 325–35.  

External links

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