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Cd3e

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Cd3e

CD3e molecule, epsilon (CD3-TCR complex)
PDB rendering based on 1xiw.
Available structures
PDB Ortholog search: RCSB
Identifiers
CD3E Gene
RNA expression pattern

CD3e molecule, epsilon also known as CD3E is a polypeptide which in humans is encoded by the CD3E gene which resides on chromosome 11.[1][2]

Function

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development.[3]

Clinical significance

Defects in this gene cause severe immunodeficiency.[4][5] This gene has also been linked to a susceptibility to type I diabetes in women.[6]

Interactions

T-cell surface glycoprotein CD3 epsilon chain has been shown to interact with TOP2B,[7] CD3EAP[8] and NCK2.[9]

See also

References


Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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