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Title: Clcn5  
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Subject: Dent's disease, Ion channels, Channelopathy, Index of biophysics articles, Erythrokeratodermia variabilis
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Chloride channel, voltage-sensitive 5

PDB rendering based on 2j9l.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; CLC5; CLCK2; ClC-5; DENTS; NPHL1; NPHL2; XLRH; XRN; hCIC-K2
External IDs IUPHAR: GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

H(+)/Cl(-) exchange transporter 5 is a protein that in humans is encoded by the CLCN5 gene.[1][2] This gene encodes a member of the ClC family of chloride ion channels and ion transporters. Mutations in this gene have been found in Dent's Disease and renal tubular disorders complicated by nephrolithiasis.[3] Although a member of a family of chloride channels, the CLCN5 protein allows movement of protons in the opposite direction of Cl(-), thus functioning as an antiporter. [4]

See also


  1. ^ Fisher SE, Black GC, Lloyd SE, Hatchwell E, Wrong O,  
  2. ^ Pook MA, Wrong O, Wooding C, Norden AG, Feest TG,  
  3. ^ "Entrez Gene: CLCN5 chloride channel 5 (nephrolithiasis 2, X-linked, Dent disease)". 
  4. ^ Picollo A, Pusch M (2005). "Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5.". Nature 436 (7049): 420–3.  

Further reading

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