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Title: Cxcl16  
Author: World Heritage Encyclopedia
Language: English
Subject: Outline of immunology, Eamonn Healy, Cytokines, CXCL15, CXCL17
Publisher: World Heritage Encyclopedia


chemokine (C-X-C motif) ligand 16
Symbol CXCL16
Alt. symbols SCYB16, SR-PSOX, CXCLG16
Entrez 58191
HUGO 16642
OMIM 605398
RefSeq NM_022059
UniProt Q9H2A7
Other data
Locus Chr. 17 p13

Chemokine (C-X-C motif) ligand 16 (CXCL16) is a small red pulp of the spleen.[1] Cells that bind and migrate in response to CXCL16 include several subsets of T cells, and natural killer T (NKT) cells.[1] CXCL16 interacts with the chemokine receptor CXCR6, also known as Bonzo.[1][3] Expression of CXCL16 is induced by the inflammatory cytokines IFN-gamma and TNF-alpha.[2] The gene for human CXCL16 is located on chromosome 17.[1]

The administration of folinic acid, which forces the methylation of CXCL 16, induces high levels of methylation of the CXCL 16 gene promoter in colon, ileum and lung and causes iNKT cells accumulation in these tissues. Colonization of neonatal GF mice, but not in adult mice, with a conventional microbiota decreases hypermethylation levels of CXCL 16.[4]


  1. ^ a b c d e Matloubian M, David A, Engel S, Ryan J, Cyster J (2000). "A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo". Nat Immunol 1 (4): 298–304.  
  2. ^ a b Abel S, Hundhausen C, Mentlein R, Schulte A, Berkhout T, Broadway N, Hartmann D, Sedlacek R, Dietrich S, Muetze B, Schuster B, Kallen K, Saftig P, Rose-John S, Ludwig A (2004). "The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10". J Immunol 172 (10): 6362–72.  
  3. ^ Wilbanks A, Zondlo S, Murphy K, Mak S, Soler D, Langdon P, Andrew D, Wu L, Briskin M (2001). "Expression cloning of the STRL33/BONZO/TYMSTRligand reveals elements of CC, CXC, and CX3C chemokines". J Immunol 166 (8): 5145–54.  
  4. ^ Olszak T, An D, Zeissig S, Vera MP, Richter J, Franke A, Glickman JN, Siebert R, Baron RM, Kasper DL, Blumberg RS (2012). "Microbial exposure during early life has persistent effects on natural killer T cell function". Science 336 (6080): 489–493.  

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