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Title: Cxcl6  
Author: World Heritage Encyclopedia
Language: English
Subject: Outline of immunology, Chromosome 4 (human), Cytokines, CXCL15, CXCL17
Publisher: World Heritage Encyclopedia


chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)
Symbol CXCL6
Alt. symbols SCYB6, GCP-2, CKA-3
Entrez 6372
HUGO 10643
OMIM 138965
RefSeq NM_002993
UniProt P80162
Other data
Locus Chr. 4 q21

Chemokine (C-X-C motif) ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family that is also known as granulocyte chemotactic protein 2 (GCP-2). As its former name suggests, CXCL6 is a chemoattractant for neutrophilic granulocytes.[1][2] It elicits its chemotactic effects by interacting with the chemokine receptors CXCR1 and CXCR2.[2] The gene for CXCL6 is located on human chromosome 4 in a cluster with other CXC chemokine genes.[3][4]


  1. ^ Proost P, Wuyts A, Conings R, Lenaerts J, Billiau A, Opdenakker G, Van Damme J (1993). "Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines". Biochemistry 32 (38): 10170–7.  
  2. ^ a b Wuyts A, Van Osselaer N, Haelens A, Samson I, Herdewijn P, Ben-Baruch A, Oppenheim J, Proost P, Van Damme J (1997). "Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties". Biochemistry 36 (9): 2716–23.  
  3. ^ Modi W, Chen Z (1998). "Localization of the human CXC chemokine subfamily on the long arm of chromosome 4 using radiation hybrids". Genomics 47 (1): 136–9.  
  4. ^ O'Donovan N, Galvin M, Morgan J (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenet Cell Genet 84 (1–2): 39–42.  

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