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Calcitonin receptor

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Title: Calcitonin receptor  
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Calcitonin receptor

Calcitonin receptor
Identifiers
Symbols  ; CRT; CT-R; CTR; CTR1
External IDs IUPHAR: ChEMBL: GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

The calcitonin receptor (CT) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis,[1] particularly with respect to bone formation and metabolism.[2][3][4]

CT works by activating the G-proteins Gs and Gq often found on osteoclasts, on cells in the kidney, and on cells in a number of regions of the brain.[5] It may also affect the ovaries in women and the testes in men.

The function of the CT receptor protein is modified through its interaction with Receptor activity-modifying proteins (RAMPs), forming the multimeric amylin receptors AMY1 (CT + RAMP1), AMY2 (CT + RAMP2), and AMY3 (CT+ RAMP3).[6]

Contents

  • Interactions 1
  • References 2
  • Further reading 3
  • External links 4

Interactions

Calcitonin receptor has been shown to interact with Apolipoprotein B[7][8] and LRP1.[9]

References

  1. ^ Purdue BW, Tilakaratne N, Sexton PM (2002). "Molecular pharmacology of the calcitonin receptor". Recept. Channels 8 (3–4): 243–55.  
  2. ^ Chambers TJ, Magnus CJ (1982). "Calcitonin alters behaviour of isolated osteoclasts". J. Pathol. 136 (1): 27–39.  
  3. ^ Dacquin R, Davey RA, Laplace C, Levasseur R, Morris HA, Goldring SR, Gebre-Medhin S, Galson DL, Zajac JD, Karsenty G (2004). "Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo". J. Cell Biol. 164 (4): 509–514.  
  4. ^ Davey RA, Turner A, McManus JF, Chiu WS, Tjahyono F, Moore AJ, Atkins GJ, Anderson PH, Ma C, Glatt V, Maclean HE, Vincent C, Bouxsein M, Morris HA, Findlay DM, Zajac JD (2008). "Calcitonin Receptor Plays a Physiological Role to Protect Against Hypercalcemia in Mice". J Bone Miner Res 23 (8): 1182–1193.  
  5. ^ senselab
  6. ^ "Calcitonin Receptors: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
  7. ^ Zhang, Jianying; Herscovitz Haya (Feb 2003). "Nascent lipidated apolipoprotein B is transported to the Golgi as an incompletely folded intermediate as probed by its association with network of endoplasmic reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin B". J. Biol. Chem. (United States) 278 (9): 7459–68.  
  8. ^ Linnik, K M; Herscovitz H (Aug 1998). "Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation state". J. Biol. Chem. (UNITED STATES) 273 (33): 21368–73.  
  9. ^ Orr, Anthony Wayne; Pedraza Claudio E; Pallero Manuel Antonio; Elzie Carrie A; Goicoechea Silvia; Strickland Dudley K; Murphy-Ullrich Joanne E (Jun 2003). "Low density lipoprotein receptor–related protein is a calreticulin coreceptor that signals focal adhesion disassembly". J. Cell Biol. (United States) 161 (6): 1179–89.  

Further reading

  • Pondel M (2001). "Calcitonin and calcitonin receptors: bone and beyond". International journal of experimental pathology 81 (6): 405–22.  
  • Gorn AH, Lin HY, Yamin M; et al. (1992). "Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line". J. Clin. Invest. 90 (5): 1726–35.  
  • Albrandt K, Brady EM, Moore CX; et al. (1995). "Molecular cloning and functional expression of a third isoform of the human calcitonin receptor and partial characterization of the calcitonin receptor gene". Endocrinology 136 (12): 5377–84.  
  • Egerton M, Needham M, Evans S; et al. (1995). "Identification of multiple human calcitonin receptor isoforms: heterologous expression and pharmacological characterization". J. Mol. Endocrinol. 14 (2): 179–89.  
  • Nussenzveig DR, Mathew S, Gershengorn MC (1995). "Alternative splicing of a 48-nucleotide exon generates two isoforms of the human calcitonin receptor". Endocrinology 136 (5): 2047–51.  
  • Nakamura M, Hashimoto T, Nakajima T; et al. (1995). "A new type of human calcitonin receptor isoform generated by alternative splicing". Biochem. Biophys. Res. Commun. 209 (2): 744–51.  
  • Pérez Jurado LA, Li X, Francke U (1995). "The human calcitonin receptor gene (CALCR) at 7q21.3 is outside the deletion associated with the Williams syndrome". Cytogenet. Cell Genet. 70 (3–4): 246–9.  
  • Nussenzveig DR, Thaw CN, Gershengorn MC (1994). "Inhibition of inositol phosphate second messenger formation by intracellular loop one of a human calcitonin receptor. Expression and mutational analysis of synthetic receptor genes". J. Biol. Chem. 269 (45): 28123–9.  
  • Kuestner RE, Elrod RD, Grant FJ; et al. (1994). "Cloning and characterization of an abundant subtype of the human calcitonin receptor". Mol. Pharmacol. 46 (2): 246–55.  
  • Frendo JL, Pichaud F, Mourroux RD; et al. (1994). "An isoform of the human calcitonin receptor is expressed in TT cells and in medullary carcinoma of the thyroid". FEBS Lett. 342 (2): 214–6.  
  • Masi L, Becherini L, Gennari L; et al. (1998). "Allelic variants of human calcitonin receptor: distribution and association with bone mass in postmenopausal Italian women". Biochem. Biophys. Res. Commun. 245 (2): 622–6.  
  • Taboulet J, Frenkian M, Frendo JL; et al. (1999). "Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women". Hum. Mol. Genet. 7 (13): 2129–33.  
  • Christopoulos G, Perry KJ, Morfis M; et al. (1999). "Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product". Mol. Pharmacol. 56 (1): 235–42.  
  • Nishikawa T, Ishikawa H, Yamamoto S, Koshihara Y (2000). "A novel calcitonin receptor gene in human osteoclasts from normal bone marrow". FEBS Lett. 458 (3): 409–14.  
  • Beaudreuil J, Taboulet J, Orcel P; et al. (2000). "Calcitonin receptor mRNA in mononuclear leucocytes from postmenopausal women: decrease during osteoporosis and link to bone markers with specific isoform involvement". Bone 27 (1): 161–8.  
  • Wada S, Yasuda S, Nagai T; et al. (2001). "Regulation of calcitonin receptor by glucocorticoid in human osteoclast-like cells prepared in vitro using receptor activator of nuclear factor-kappaB ligand and macrophage colony-stimulating factor". Endocrinology 142 (4): 1471–8.  
  • Ogden CA, deCathelineau A, Hoffmann PR; et al. (2001). "C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells". J. Exp. Med. 194 (6): 781–95.  
  • Nosaka Y, Tachi Y, Shimpuku H; et al. (2002). "Association of calcitonin receptor gene polymorphism with early marginal bone loss around endosseous implants". The International journal of oral & maxillofacial implants 17 (1): 38–43.  
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.  

External links

  • "Calcitonin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
  • Calcitonin receptors at the US National Library of Medicine Medical Subject Headings (MeSH)


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