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Corticotropin releasing hormone receptor 1

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Title: Corticotropin releasing hormone receptor 1  
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Subject: Corticotropin-releasing hormone, HEK 293 cells, Urocortin, Small nucleolar RNA SNORD115, List of human hormones
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Corticotropin releasing hormone receptor 1

Corticotropin releasing hormone receptor 1
Available structures
PDB Ortholog search: RCSB
CRHR1 Gene
RNA expression pattern

Corticotropin releasing hormone receptor 1 (CRHR1) is a protein, also known as CRF1, with the latter (CRF1) now being the IUPHAR-recommended name.[1] In humans, CRF1 is encoded by the CRHR1 gene.[2][3]


The corticotropin-releasing hormone receptor binds to corticotropin-releasing hormone, a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress.[4]

CRF1 receptors in mice mediate ethanol enhancement of GABAergic synaptic transmission.[5]

Clinical significance

Variations in the CRHR1 gene is associated with enhanced response to inhaled corticosteroid therapy in asthma.[6]

CRF1 triggers cells to release hormones that are linked to stress and anxiety.[7] Hence CRF1 receptor antagonists are being actively studied as possible treatments for depression and anxiety.[8][9]


Corticotropin releasing hormone receptor 1 has been shown to interact with Corticotropin-releasing hormone[10][11] and Urocortin.[12]

See also


Further reading

External links

  • Medical Subject Headings (MeSH)
  • Medical Subject Headings (MeSH)

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