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Title: Dimemorfan  
Author: World Heritage Encyclopedia
Language: English
Subject: Dextromethorphan, Sigma receptor, L-687,384, Ditolylguanidine, PRE-084
Collection: Antitussives, Morphinans
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
Clinical data
Legal status
CAS number  YesY
ATC code R05
ChemSpider  YesY
Chemical data
Formula C18H25N 
Mol. mass 255.398 g/mol

Dimemorfan is an antitussive or cough suppressant which acts as a sigma receptor agonist.[1][2] It is an analogue of dextromethorphan and dextrorphan, but lacks significant NMDA receptor antagonistic action and dissociative effects, thereby having reduced abuse potential and adverse effects in comparison.[3]

See also


  1. ^ Wang, H. H.; Chien, J. W.; Chou, Y. C.; Liao, J. F.; Chen, C. F. (2003). "Anti-amnesic effect of dimemorfan in mice". British Journal of Pharmacology 138 (5): 941–949.  
  2. ^ Shin, E. J.; Nah, S. Y.; Kim, W. K.; Ko, K. H.; Jhoo, W. K.; Lim, Y. K.; Cha, J. Y.; Chen, C. F.; Kim, H. C. (2005). "The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via σ1 receptor activation: Comparison with the effects of dextromethorphan". British Journal of Pharmacology 144 (7): 908–918.  
  3. ^ Chou, Y. C.; Liao, J. F.; Chang, W. Y.; Lin, M. F.; Chen, C. F. (1999). "Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan". Brain Research 821 (2): 516–519.  
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