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Title: Diphenadione  
Author: World Heritage Encyclopedia
Language: English
Subject: ATC code B01, Vitamin K antagonist
Publisher: World Heritage Encyclopedia


CAS number 82-66-6 YesY
PubChem 6719
ChemSpider 6463
KEGG D07136 YesY
ATC code AA10
Jmol-3D images Image 1
Molecular formula C23H16O3
Molar mass 340.37 g mol−1
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Diphenadione is a vitamin K antagonist which has anticoagulant effects and is used as a rodenticide against rats, mice, voles, ground squirrels and other rodents. This chemical compound is an anti-coagulant with longer activity than warfarin and other synthetic indandione anticoagulants.[1]

Safety and toxicity

Diphenadione is highly toxic for human skin by all means of contact. The consumption of drug may cause major blood clotting and irregular heartbeats.[2] An online pesticide database gives more information about the safety of diphenadione.[3] The U.S. Environmental Protection Agency has issued a safety handbook which explains how incidents of poisoning with similar rodenticides are usually treated.[4] For treatment purposes Vitamin K antagonists like diphenadione are placed under the heading of coumarins and indandiones. The handbook notes that " agents specifically designed to kill mammals, often their toxicity is very similar for the target rodents and for humans."[5]


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