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Title: Gpr143  
Author: World Heritage Encyclopedia
Language: English
Subject: Microphthalmia-associated transcription factor
Publisher: World Heritage Encyclopedia


G protein-coupled receptor 143
GPR143 Gene
RNA expression pattern
Ocular albinism type 1 protein
Symbol Ocular_alb
Pfam Pfam clan InterPro IPR001414

G-protein coupled receptor 143 is a protein encoded by the GPR143 gene in humans.[1][2][3]

Ocular albinism type 1 protein is a conserved integral membrane protein with seven transmembrane domains. It is expressed in the eye and epidermal melanocytes.[3]

The GPR143 gene is regulated by the Microphthalmia-associated transcription factor.[4][5]

L-DOPA is an endogenous ligand for OA1.[6]


GPR143 has been shown to interact with GNAI1.[2]


Further reading

External links

  • GeneReviews/NCBI/NIH/UW entry on Ocular Albinism, X-Linked

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