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Title: Gpr35  
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Subject: Kynurenic acid, Lysophosphatidic acid
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G protein-coupled receptor 35
GPR35 Gene
RNA expression pattern

G protein-coupled receptor 35 also known as GPR35 is a G protein-coupled receptor which in humans is encoded by the GPR35 gene.[1] Heightened expression of GPR35 is found in immune and gastrointestinal tissues, including the crypts of Lieberkühn.



Selective agonists of GPR35 include:


Antagonists of GPR35 include:

  • ML145 (CID-2286812)[5]
  • ML144 (CID-1542103)[5]

Clinical significance

Deletion of GPR35 gene may be responsible for brachydactyly mental retardation syndrome and is mutated in 2q37 monosomy and 2q37 deletion syndrome.[6] In one study GPR35 has been recognised as a potential oncogene in the stomach cancer.[7]


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