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Hla-dmb

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Title: Hla-dmb  
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Subject: Immunoglobulin domain, MHC class II, HLA-DM
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Hla-dmb

Major histocompatibility complex, class II, DM beta
PDB rendering based on 1hdm.
Available structures
PDB Ortholog search: RCSB
Identifiers
HLA-DMB Gene
RNA expression pattern

HLA class II histocompatibility antigen, DM beta chain is a protein that in humans is encoded by the HLA-DMB gene.[1][2]

HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.[2]

References

Further reading


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