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Title: Il17ra  
Author: World Heritage Encyclopedia
Language: English
Subject: CXCR6, IL3RA, CCR9, C-C chemokine receptor type 7, CCR8 (gene)
Collection: Clusters of Differentiation, Il17 Family Cytokine Receptors
Publisher: World Heritage Encyclopedia


Interleukin 17 receptor A
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; CANDF5; CD217; CDw217; IL-17RA; IL17R; hIL-17R
External IDs GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Interleukin 17 receptor A, also known as IL17RA and CDw217 (cluster of differentiation w217), is a human gene.[1] Interleukin 17A (IL17A)is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure.[1]


  • See also 1
  • References 2
  • Further reading 3
  • External links 4

See also


  1. ^ a b "Entrez Gene: IL17RA interleukin 17 receptor A". 

Further reading

  • Yao Z, Spriggs MK, Derry JM, et al. (1998). "Molecular characterization of the human interleukin (IL)-17 receptor". Cytokine 9 (11): 794–800.  
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95.  
  • Honorati MC, Meliconi R, Pulsatelli L, et al. (2001). "High in vivo expression of interleukin-17 receptor in synovial endothelial cells and chondrocytes from arthritis patients". Rheumatology (Oxford) 40 (5): 522–7.  
  • Footz TK, Brinkman-Mills P, Banting GS, et al. (2001). "Analysis of the Cat Eye Syndrome Critical Region in Humans and the Region of Conserved Synteny in Mice: A Search for Candidate Genes at or near the Human Chromosome 22 Pericentromere". Genome Res. 11 (6): 1053–70.  
  • Haudenschild D, Moseley T, Rose L, Reddi AH (2002). "Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer". J. Biol. Chem. 277 (6): 4309–16.  
  • Kehlen A, Thiele K, Riemann D, Langner J (2002). "Expression, modulation and signalling of IL-17 receptor in fibroblast-like synoviocytes of patients with rheumatoid arthritis". Clin. Exp. Immunol. 127 (3): 539–46.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.  
  • Steiner GE, Newman ME, Paikl D, et al. (2003). "Expression and function of pro-inflammatory interleukin IL-17 and IL-17 receptor in normal, benign hyperplastic, and malignant prostate". Prostate 56 (3): 171–82.  
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7.  
  • McAllister F, Henry A, Kreindler JL, et al. (2005). "Role of IL-17A, IL-17F, and the IL-17 Receptor in Regulating Growth-Related Oncogene-α and Granulocyte Colony-Stimulating Factor in Bronchial Epithelium: Implications for Airway Inflammation in Cystic Fibrosis". J. Immunol. 175 (1): 404–12.  
  • Pongcharoen S, Niumsup P, Sanguansermsri D, et al. (2006). "The effect of interleukin-17 on the proliferation and invasion of JEG-3 human choriocarcinoma cells". Am. J. Reprod. Immunol. 55 (4): 291–300.  
  • Toy D, Kugler D, Wolfson M, et al. (2006). "Cutting edge: interleukin 17 signals through a heteromeric receptor complex". J. Immunol. 177 (1): 36–9.  
  • Wang X, Dong Z, Zhu DD, Guan B (2006). "Expression profile of immune-associated genes in nasal polyps". Ann. Otol. Rhinol. Laryngol. 115 (6): 450–6.  
  • Rong Z, Cheng L, Ren Y, et al. (2007). "Interleukin-17F signaling requires ubiquitination of interleukin-17 receptor via TRAF6". Cell. Signal. 19 (7): 1514–20.  
  • Maitra A, Shen F, Hanel W, et al. (2007). "Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression". Proc. Natl. Acad. Sci. U.S.A. 104 (18): 7506–11.  

External links

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