Il4r

Interleukin 4 receptor
PDB rendering based on 1iar.
Available structures
PDB Ortholog search: RCSB
Identifiers
IL4R Gene
RNA expression pattern
Interleukin-4 receptor alpha chain, N-terminal
interleukin-4 / receptor alpha chain complex
Identifiers
Symbol IL4Ra_N
Pfam InterPro IPR015319
SCOP SUPERFAMILY 1iar

Interleukin 4 receptor is a type I cytokine receptor. IL4R is its human gene.

Function

This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Among T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitis, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.[1]

The binding of IL-4 or IL-13 to the IL-4 receptor on the surface of macrophages results in the alternative activation of those macrophages. Alternatively activated macrophages (AAMΦ) downregulate inflammatory mediators such as IFNγ during immune responses, particularly with regards to helminth infections.[2]

Interactions

Interleukin-4 receptor has been shown to interact with SHC1.[3][4]

Structure

The N-terminal (extracellular) portion of interleukin-4 is related in overall topology to fibronectin type III modules and folds into a sandwich comprising seven antiparallel beta sheets arranged in a three-strand and a four-strand beta-pleated sheet. They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response.[5]

See also

References

Further reading

External links

  • Medical Subject Headings (MeSH)

This article incorporates text from the IPR015319


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