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Title: Ibalizumab  
Author: World Heritage Encyclopedia
Language: English
Subject: List of therapeutic monoclonal antibodies
Publisher: World Heritage Encyclopedia


Ibalizumab (TMB-355[1] previously known as TNX-355) is a non-immunosuppressive monoclonal antibody that binds CD4, the primary receptor for HIV, and inhibits the viral entry process.[2] It is being investigated as an HIV entry inhibitor[3] with the ability to block both CCR5- and CXCR4-tropic viruses,[4] and is currently undergoing a Phase II clinical trial with an estimated study completion date in December 2010.[5] Specific Research is also conducted at the Aaron Diamond AIDS Research Center under the direction of David Ho.[6][7]

Results from a previous Phase II of ibalizumab, reported by the original developer Tanox in 2006,[4] showed that HIV-infected patients who received the drug, in combination with an optimized background regimen (OBR), maintained a considerably greater reduction in viral load and experienced a statistically significant increase in CD4+ cells than did patients given placebo in combination with OBR. Thus, pending results of further trials, it is presently one of a limited number of viable alternative strategies to contain the virus without recourse to antiretroviral drug cocktails or a vaccine.


Ibalizumab is currently being developed by TaiMed Biologics but was originally developed by Tanox, now part of Genentech. As part of Genentech's takeover of Tanox, the patent for ibalizumab was sold to TaiMed Biologics, a biotech company formed in 2007 with support from the Taiwanese Government through a $20 million investment by the state-owned National Development Fund.[8][9][10]

See also


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