Interstitial Cells of Cajal

For the cell in the midbrain, see Rostral interstitial nucleus of medial longitudinal fasciculus.
Interstitial cell of Cajal
Latin cellulae interstitiales stimulantes[1]

The interstitial cell of Cajal (ICC) is a type of interstitial cell found in the gastrointestinal tract that serves as a pacemaker which creates the bioelectrical slow wave potential that leads to contraction of the smooth muscle.[2]

Many types of smooth muscle tissues have now been shown to contain ICC, but with few exceptions the function of these cells is not known and is currently an area of active research. An international society (International Society for ICC, www.isicc.org) has recently been formed to provide a forum to discuss research in ICC in a variety of tissues.

These cells are derived from mesoderm.[3]

Role in slow wave activity

ICC

Frequency of ICC pacemaker cells

The frequency of ICC pacemaker activity differs in different regions of the GI tract:

ICC also mediate neural input from enteric motor neurons. Animals lacking ICC have greatly reduced responses to the neurotransmitter acetylcholine, released from excitatory motor neurons, and to the transmitter nitric oxide, released from inhibitory motor neurons. Loss of ICC in disease, therefore, may interrupt normal neural control of gastrointestinal (GI) contractions and lead to functional GI disorders, such as irritable bowel syndrome.

ICC also express mechano-sensitive mechanisms that cause these cells to respond to stretch. Stretching GI muscles can affect the resting potentials of ICC and affect the frequency of pacemaker activity.

ICC are also critical in the propagation of electrical slow waves. ICC form a network through which slow wave activity can propagate. If this network is broken, then 2 regions of muscle will function independently.

Pathology

ICCs are thought to be the cells from which gastrointestinal stromal tumours (GISTs) arise.[4] Also, abnormalities in the ICC network is one cause of chronic intestinal pseudo-obstruction.[5]

Eponym

The interstitial cells of Cajal are named after Santiago Ramón y Cajal,[6] a Spanish pathologist and Nobel laureate.

References

External links

  • Overview of ICCs - unr.edu.
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