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Janus kinase 1

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Title: Janus kinase 1  
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Subject: Janus kinase, Jak, GRB2, IL-2 receptor, PTPN11, Interleukin 15, Glycoprotein 130, STAT3, Tyrosine kinase 2, Non-receptor tyrosine kinase
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Janus kinase 1

Janus kinase 1
3EYG.
Available structures
PDB Ortholog search: RCSB
Identifiers
2.7.10.2
RNA expression pattern

JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). It is also important for transducing a signal by type I (IFN-α/β) and type II (IFN-γ) interferons, and members of the IL-10 family via type II cytokine receptors.[1] Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Loss of Jak1 is lethal in neonatal mice, possibly due to difficulties suckling.[2] Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body.[3]

Interactions

Janus kinase 1 has been shown to interact with PTPN11,[4][5] Glycoprotein 130,[6][7][8] Interleukin 10 receptor, alpha subunit,[9][10] ELP2,[11] STAT3,[12][13] Grb2,[14][15] STAT5A,[16] STAT5B,[16] IL2RB,[10][17][18][19][20] TNFRSF1A,[21][22] IRS1,[23][24] GNB2L1[25] and STAM2.[26][27]

References

Further reading

External links

  • Medical Subject Headings (MeSH)

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