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Title: Kir3dl1  
Author: World Heritage Encyclopedia
Language: English
Subject: Killer-cell immunoglobulin-like receptor, CD3 (immunology), CD79B, IL18R1, CD16
Collection: Clusters of Differentiation, Immunoglobulin Superfamily
Publisher: World Heritage Encyclopedia


Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; CD158E1; KIR; KIR3DL1/S1; NKAT-3; NKAT3; NKB1; NKB1B
External IDs GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Killer cell immunoglobulin-like receptor 3DL1 is a protein that in humans is encoded by the KIR3DL1 gene.[1][2][3] Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte immunoglobulin-like receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.[3]

See also


  1. ^ Colonna M, Samaridis J (May 1995). "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells". Science 268 (5209): 405–8.  
  2. ^ Wagtmann N, Biassoni R, Cantoni C, Verdiani S, Malnati MS, Vitale M, Bottino C, Moretta L, Moretta A, Long EO (Jun 1995). "Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains". Immunity 2 (5): 439–49.  
  3. ^ a b "Entrez Gene: KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1". 

Further reading

  • Selvakumar A, Steffens U, Dupont B (1997). "Polymorphism and domain variability of human killer cell inhibitory receptors.". Immunol. Rev. 155 (1): 183–96.  
  • D'Andrea A, Chang C, Franz-Bacon K, et al. (1995). "Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes.". J. Immunol. 155 (5): 2306–10.  
  • Litwin V, Gumperz J, Parham P, et al. (1994). "NKB1: a natural killer cell receptor involved in the recognition of polymorphic HLA-B molecules.". J. Exp. Med. 180 (2): 537–43.  
  • Döhring C, Samaridis J, Colonna M (1996). "Alternatively spliced forms of human killer inhibitory receptors.". Immunogenetics 44 (3): 227–30.  
  • Pende D, Biassoni R, Cantoni C, et al. (1996). "The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer.". J. Exp. Med. 184 (2): 505–18.  
  • Wagtmann N, Rajagopalan S, Winter CC, et al. (1996). "Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer.". Immunity 3 (6): 801–9.  
  • Valiante NM, Uhrberg M, Shilling HG, et al. (1998). "Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors.". Immunity 7 (6): 739–51.  
  • Uhrberg M, Valiante NM, Shum BP, et al. (1998). "Human diversity in killer cell inhibitory receptor genes.". Immunity 7 (6): 753–63.  
  • Vyas Y, Selvakumar A, Steffens U, Dupont B (1999). "Multiple transcripts of the killer cell immunoglobulin-like receptor family, KIR3DL1 (NKB1), are expressed by natural killer cells of a single individual.". Tissue Antigens 52 (6): 510–9.  
  • Kwon D, Chwae YJ, Choi IH, et al. (2000). "Diversity of the p70 killer cell inhibitory receptor (KIR3DL) family members in a single individual.". Mol. Cells 10 (1): 54–60.  
  • Crum KA, Logue SE, Curran MD, Middleton D (2001). "Development of a PCR-SSOP approach capable of defining the natural killer cell inhibitory receptor (KIR) gene sequence repertoires.". Tissue Antigens 56 (4): 313–26.  
  • Gardiner CM, Guethlein LA, Shilling HG, et al. (2001). "Different NK cell surface phenotypes defined by the DX9 antibody are due to KIR3DL1 gene polymorphism.". J. Immunol. 166 (5): 2992–3001.  
  • Yamochi T, Semba K, Tsuji K, et al. (2002). "ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3).". Eur. J. Biochem. 268 (23): 6076–82.  
  • Shilling HG, Guethlein LA, Cheng NW, et al. (2002). "Allelic polymorphism synergizes with variable gene content to individualize human KIR genotype.". J. Immunol. 168 (5): 2307–15.  
  • Martin MP, Gao X, Lee JH, et al. (2002). "Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS.". Nat. Genet. 31 (4): 429–34.  
  • Chwae YJ, Chang MJ, Park SM, et al. (2002). "Molecular mechanism of the activation-induced cell death inhibition mediated by a p70 inhibitory killer cell Ig-like receptor in Jurkat T cells.". J. Immunol. 169 (7): 3726–35.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.  

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