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Leukotriene B4

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Title: Leukotriene B4  
Author: World Heritage Encyclopedia
Language: English
Subject: Arachidonic acid, Leukotriene receptor, Arachidonic acid 5-hydroperoxide, Leukotriene E4, Cysteinyl leukotriene receptor
Collection: Eicosanoids
Publisher: World Heritage Encyclopedia
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Leukotriene B4

Leukotriene B4
Names
IUPAC name
(5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-6,8,10,14-icosatetraenoic acid
Identifiers
 Y
ChEBI  N
ChEMBL  N
ChemSpider  N
Jmol-3D images Image
KEGG  N
PubChem
Properties
C20H32O4
Molar mass 336.466
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N  (: Y/N?)

Leukotriene B4 is a leukotriene involved in inflammation. It is produced from leukocytes in response to inflammatory mediators and is able to induce the adhesion and activation of leukocytes on the endothelium, allowing them to bind to and cross it into the tissue.[1] In neutrophils, it is also a potent chemoattractant, and is able to induce the formation of reactive oxygen species and the release of lysosome enzymes by these cells.[1] It is synthesized by leukotriene-A4 hydrolase from leukotriene A4.[2]

Eicosanoid synthesis. (Leukotrienes at right.)

References

  1. ^ a b Cotran; Kumar, Collins. Robbins Pathologic Basis of Disease. Philadelphia: W.B Saunders Company.  
  2. ^ http://www.uniprot.org/uniprot/P09960. Retrieved 9 April 2013. 


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