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Luteinizing hormone beta polypeptide

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Title: Luteinizing hormone beta polypeptide  
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Subject: Female infertility, LHB
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Luteinizing hormone beta polypeptide

Luteinizing hormone beta polypeptide
Available structures
PDB Ortholog search: RCSB
LHB Gene
RNA expression pattern

Luteinizing hormone subunit beta also known as lutropin subunit beta is a protein that in humans is encoded by the LHB gene.[1][2]


The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3.[2] In equines, this subunit is encoded by the same gene as the beta subunit of chorionic gonadatropin, subunits which are identical.[3]


This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and a unique beta subunit (this protein) which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.[2]

Clinical significance

Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism.[2]


Further reading

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