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Pvrl2

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Pvrl2

Poliovirus receptor-related 2 (herpesvirus entry mediator B)
Available structures
PDB Ortholog search: RCSB
Identifiers
PVRL2 Gene
RNA expression pattern

Poliovirus receptor-related 2 (herpesvirus entry mediator B, nectin-2), also known as PVRL2 and CD112 (Cluster of Differentiation 112), is a human gene.[1]

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[1]

See also

References

Further reading

External links

  • Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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