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Prokaryotic elongation factors

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Title: Prokaryotic elongation factors  
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Subject: Prokaryotic translation, Elongation factor, Eukaryotic elongation factors, Protein biosynthesis, Prokaryotic initiation factor
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Prokaryotic elongation factors

EF-Tu was PDB Molecule of the Month pdb81_1 on September 2006

In prokaryotes, four elongation factors are required for translation: EF-Tu, EF-Ts, EF-G and EF-P.

  • EF-Tu mediates the entry of the aminoacyl tRNA into a free site of the ribosome.
  • EF-Ts serves as the guanine nucleotide exchange factor for EF-Tu, catalyzing the release of GDP from EF-Tu.
  • EF-G catalyzes the translocation of the tRNA and mRNA down the ribosome at the end of each round of polypeptide elongation.
  • EF-P stimulates peptide formation by catalyzing the first synthesis step between the first amino acid (N-formylmethionine) and the second amino acid.

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