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Title: Rheb  
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Subject: Tuberous sclerosis, Tuberous sclerosis protein
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Ras homolog enriched in brain
PDB rendering based on 1xtq.
Available structures
PDB Ortholog search: RCSB
RNA expression pattern

GTP-binding protein Rheb also known as Ras homolog enriched in brain (RHEB) is a protein that in humans is encoded by the RHEB gene.[1]


Rheb is a recently discovered member of the Ras superfamily that may be involved in neural plasticity. This function is novel and not typically associated with the Ras proteins.

This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin / TOR / S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22.[2]


RHEB has been shown to interact with C-Raf,[3][4][5] Mammalian target of rapamycin,[3][6][7][8] TSC2,[3][9][10][11][12][13] Ataxia telangiectasia mutated,[3] KIAA1303[3] and Ataxia telangiectasia and Rad3 related.[3]


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