Rnase1

Ribonuclease, RNase A family, 1 (pancreatic)
PDB rendering based on 1dza.
Available structures
PDB Ortholog search: RCSB
Identifiers
3.1.27.5
RNA expression pattern

Ribonuclease pancreatic is an enzyme that in humans is encoded by the RNASE1 gene.[1][2]

This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ss-RNA over ds-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.[2]

References

Further reading


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