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Relaxin receptor

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Relaxin receptor

relaxin/insulin-like family peptide receptor 1
Identifiers
Symbol RXFP1
Alt. symbols LGR7
Entrez HUGO OMIM RefSeq UniProt Locus q31.3
relaxin/insulin-like family peptide receptor 2
Identifiers
Symbol RXFP2
Alt. symbols LGR8, GREAT, GPR106, INSL3R
Entrez HUGO OMIM RefSeq UniProt Locus q12.3
relaxin/insulin-like family peptide receptor 3
Identifiers
Symbol RXFP3
Alt. symbols RLN3R1, SALPR, GPCR135
Entrez HUGO OMIM RefSeq UniProt Locus p15.1-p14
relaxin/insulin-like family peptide receptor 4
Identifiers
Symbol RXFP4
Alt. symbols GPR100, GPCR142, RLN3R2
Entrez HUGO OMIM RefSeq UniProt Locus q22

The relaxin receptors are a subclass of four closely related G protein-coupled receptors that bind relaxin peptide hormones.[1][2]

Below is list of human relaxin receptors, their endogenous peptide hormones, and what down stream enzymes are activated or inhibited by the receptor.

receptor/gene ligands activates inhibits
RXFP1 Relaxin 1, Relaxin 2, Relaxin 3 adenylate cyclase, protein kinase A, protein kinase C,

phosphatidylinositol 3-kinase, extracellular signal-regulated kinases (Erk1/2)

RXFP2 Relaxin 1, Relaxin 2, INSL3 adenylate cyclase
RXFP3 Relaxin 3 Erk1/2 signaling adenylate cyclase
RXFP4 Relaxin 3, INSL3 adenylate cyclase

See also

  • Relaxin family peptide hormones
  • Relaxin-3

References

External links

  • Medical Subject Headings (MeSH)
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